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Facts and News

Welcome on the web pages of the German Hyperoxaluria Center

In a special outpatient clinic at the Children's Kidney Center in Bonn (www.knz-bonn.de), we care for pediatric and adult patients with primary and secondary hyperoxaluria. In collaboration with the Wisplinghoff lab in Cologne, we offer the analysis of all substances of the glyoxylate/oxalate metabolism, so that diagnosis is quickly establish and/or an adequate treatment control is possible. The second backbone of the GHC is genetic diagnostics, which is carried out in collaboration with the Institute of Human Genetics of the University Hospital of Cologne.

An increased excretion of oxalate in the urine..
Either it is produced in extremely high amounts in the liver (due to a congenital disease) or too much oxalate is absorbed through the intestine, e.g. after ingestion of food rich in oxalate (e.g. spinach).
Oxalate must be excreted via the kidneys because the body cannot do anything with it, in urine it binds to calcium and this results in kidney stone formation or renal calcification.
The oxalate and also the recurrent kidney stones or progressive nephrocalcinosis can damage the kidneys severely until renal failure occurs.
The oxalate is no longer excreted and accumulate in blood and later in body tissue, as no form of dialysis treatment can sufficiently remove oxalate.
Congenital oxalate disorders have been treated with transplantation, but new drugs are now available, which help to avoid kidney failure. Further research is needed to find even better medications.

About us


the European advocacy group for patients with primary hyperoxaluria


the European advocacy group for patients with enteric hyperoxaluria


Self-help primary hyperoxaluria e.V.

Our Team

Prof. Dr. Bernd Hoppe

Dr. Cristina Martin-Higueras

Dr. Lodovica Borghese

Susanne Herz

Katja Theisen

Priv.-Doz. Dr. Bodo Beck

Dr. Gesa Schalk


Contact us


Deutsches Hyperoxaluriezentrum, c/o Kindernierenzentrum Bonn, Dr. Gesa Schalk & Prof. Dr. Bernd Hoppe, Im Mühlenbach 2b, 53127 Bonn

+49 (0)228 6883860